2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

Base Information

Chemical Name:2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid
CAS No.:1427330-94-6
Molecular Formula:C₂₂H₁₈F₃NO₃
Molecular Weight:401.385
Hs Code.:

Synonyms:2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

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Chemical Property of 2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

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Technology Process of 2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

There total 6 articles about 2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1427406-76-5
C₂₅H₂₄F₃NO₃

: 1427330-94-6
2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1427330-97-9
3-amino-2 ,4-difluoro-phenol

: 1427330-94-6
2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / N,N-dimethyl-formamide / 0.58 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 1 h / 100 °C / Microwave irradiation

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / Reflux

4: water; sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1427406-74-3
isopropyl 2-(3-amino-2,4-difluoro-phenoxy)acetate

: 1427330-94-6
2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 100 °C / Microwave irradiation

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / Reflux

3: water; sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;