N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide

Base Information

• Chemical Name: N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide
• CAS No.: 220052-61-9
• Molecular Formula: C₁₉H₂₇IN₂O₃
• Molecular Weight: 458.339

Synonyms:N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide

Chemical Property of N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide

There total 3 articles about N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Nα-tert-butoxycarbonyl-L-phenylalanine (2S)-hydroxymethylpyrrolidinyl amide (182815-41-4) → Nα-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide (220052-61-9)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In toluene; for 1.5h; Ambient temperature;

DOI:10.1016/S0968-0896(98)00162-X

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Nα-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide (220052-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluorobirate / dimethylformamide / 5 h / Ambient temperature

2: 64 percent / iodine, triphenylphosphine, imidazole / toluene / 1.5 h / Ambient temperature

With 1H-imidazole; iodine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triphenylphosphine; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0968-0896(98)00162-X

Reference yield:

(S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → Nα-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide (220052-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluorobirate / dimethylformamide / 5 h / Ambient temperature

2: 64 percent / iodine, triphenylphosphine, imidazole / toluene / 1.5 h / Ambient temperature

With 1H-imidazole; iodine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triphenylphosphine; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0968-0896(98)00162-X

upstream raw materials:

N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-hydroxymethylpyrrolidinyl amide

N-tert-butoxycarbonyl-L-phenylalanine

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

N^α-9-fluorenylmethoxycarbonyl-L-methionyl-L-threonyl-L-methionyl-L-valyl-L-leucyl-L-seryl-L-phenylalanine (2R)-methylpyrrolidinyl amide

N^α-tert-butoxycarbonyl-L-phenylalanine (2R)-methylpyrrolidinyl amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 220052-61-9 N^α-tert-butoxycarbonyl-L-phenylalanine (2S)-iodomethylpyrrolidinyl amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send