4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:207562-20-7
Molecular Formula:C₂₄H₂₆O₄Si
Molecular Weight:406.554
Hs Code.:

Synonyms:4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

There total 8 articles about 4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 135-19-3
β-naphthol

: 1026962-95-7
4-Chlorocarbonylmethyl-benzoic acid 2-trimethylsilanyl-ethyl ester

: 207562-20-7
4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With triethylamine; In diethyl ether; at 0 - 20 ℃;
DOI:10.1248/cpb.46.591

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 207562-20-7
4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / Pd(OAc)2, 1,3-bis(diphenylphosphino)propane, Et₃N / dimethylformamide / 24 h / 80 °C / 760 Torr

2: 83 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

3: 100 percent / oxalyl chloride / toluene / 40 °C

4: 62 percent / Et₃N / diethyl ether / 0 - 20 °C

With palladium diacetate; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.46.591

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 207562-20-7
4-(Naphthalen-2-yloxycarbonylmethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / pyridine / CH₂Cl₂ / 0.75 h / 0 °C

2: 92 percent / TFA, aq. NaOH / 9 h / 72 °C

3: 95 percent / K₂CO₃ / acetone / 4 h / Heating

4: 79 percent / Pd(OAc)2, 1,3-bis(diphenylphosphino)propane, Et₃N / dimethylformamide / 24 h / 80 °C / 760 Torr

5: 83 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

6: 100 percent / oxalyl chloride / toluene / 40 °C

7: 62 percent / Et₃N / diethyl ether / 0 - 20 °C

With pyridine; palladium diacetate; sodium hydroxide; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1248/cpb.46.591