N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

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Chemical Name:N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide
CAS No.:916052-24-9
Molecular Formula:C₂₁H₁₇ClN₄O₃S₂
Molecular Weight:472.976
Hs Code.:

Synonyms:N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

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Chemical Property of N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

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Technology Process of N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

There total 4 articles about N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 916050-72-1
(5Z)-2-{[5-(aminomethyl)-2-chlorophenyl]amino}-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

: 124-63-0
methanesulfonyl chloride

: 916052-24-9
N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

Guidance literature:: (5Z)-2-{[5-(aminomethyl)-2-chlorophenyl]amino}-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one; methanesulfonyl chloride; With pyridine; at 20 ℃; for 5h;

With sodium hydroxide; In pyridine; water; pH=13;

With acetic acid; In pyridine; water;

Reference yield:

: 1,1-dimethylethyl ({4-chloro-3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}methyl)carbamate

: 916052-24-9
N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperdinium acetate / ethanol; toluene / 18 h / Heating / reflux

2.1: trifluoroacetic acid / 0.33 h

2.3: pH 8

3.1: pyridine / 5 h / 20 °C

3.2: pH 13

With pyridine; piperdinium acetate; trifluoroacetic acid; In ethanol; toluene;

Reference yield:

: 180081-30-5
N-(3-amino-4-chlorophenylmethyl)carbamic acid t-butyl ester

: 916052-24-9
N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 40 h / Heating / reflux

2.1: piperdinium acetate / ethanol; toluene / 18 h / Heating / reflux

3.1: trifluoroacetic acid / 0.33 h

3.3: pH 8

4.1: pyridine / 5 h / 20 °C

4.2: pH 13

With pyridine; piperdinium acetate; trifluoroacetic acid; In ethanol; toluene;