N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine

Base Information

• Chemical Name: N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine
• CAS No.: 1421632-78-1
• Molecular Formula: C₂₇H₃₇N₅O₅SSi
• Molecular Weight: 571.773

Synonyms:N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine

Chemical Property of N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine

There total 3 articles about N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

thiobenzoic acid (98-91-9) + N2-isobutyryl-5'-O-tert-butyldimethylsilyl-2'-deoxyxyloguanosine (195375-51-0) → N2-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine (1421632-78-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h; Inert atmosphere;

DOI:10.1039/c2ob26940f

Reference yield:

C20H31N5O5Si → N2-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine (1421632-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / dichloromethane; isopropyl alcohol / -60 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4.5 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 2: |Mitsunobu Displacement;

DOI:10.1039/c2ob26940f

Reference yield:

N2-isobutyryl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyguanosine (85326-10-9) → N2-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine (1421632-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 5.17 h / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate / dichloromethane; isopropyl alcohol / -60 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4.5 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 3: |Mitsunobu Displacement;

DOI:10.1039/c2ob26940f

upstream raw materials:

thiobenzoic acid

N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-2'-deoxyxyloguanosine

N²-isobutyryl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyguanosine

Downstream raw materials:

N²-isobutyryl-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine

N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine

N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine

N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thio-guanosine-3'-S-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1421632-78-1 N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-3'-S-benzoyl-2'-deoxy-3'-thioguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send