N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide
CAS No.:1383988-08-6
Molecular Formula:C₂₆H₂₀FN₅O₄S
Molecular Weight:517.54
Hs Code.:

Synonyms:N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

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Chemical Property of N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

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Technology Process of N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

There total 3 articles about N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.58%

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 1383987-90-3
2-amino-6-(5-amino-6-methoxypyridin-3-yl)-3-phenylquinazolin-4(3H)-one

: 1383988-08-6
N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 3h;

Reference yield:

: 893440-50-1
2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine

: 1383988-08-6
N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 65 °C / Inert atmosphere

2: pyridine / 3 h / 20 °C

With pyridine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water;

Reference yield:

: 223704-97-0
2-amino-6-iodo-3-phenylquinazolin-4(3H)-one

: 1383988-08-6
N-[5-(2-amino-4-oxo-3-phenyl-3,4-dihydro-6-quinazolinyl)-2-(methyloxy)-3-pyridinyl]-2-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / 65 °C / Inert atmosphere

2: pyridine / 3 h / 20 °C

With pyridine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water;