3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

Base Information

Chemical Name:3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole
CAS No.:1402727-31-4
Molecular Formula:C₂₇H₂₂N₄O
Molecular Weight:418.498
Hs Code.:

Synonyms:3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

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Chemical Property of 3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

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Technology Process of 3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

There total 5 articles about 3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1402728-60-2
(1E,6E)-1-(1H-indol-5-yl)-7-[4-(2-pyridylmethoxy)phenyl]hepta-1,6-diene-3,5-dione

: 1402727-31-4
3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

Guidance literature:: With hydrazine hydrate; acetic acid; at 60 ℃; for 3h;

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1402727-31-4
3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 50 °C

2.1: boron trioxide; Triisopropyl borate / ethyl acetate / 1 h / 70 °C

2.2: 1 h

3.1: hydrazine hydrate; acetic acid / 3 h / 60 °C

With Triisopropyl borate; caesium carbonate; hydrazine hydrate; acetic acid; boron trioxide; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1402727-31-4
3-[(1E)-2-(1H-indol-5-yl)ethenyl]-5-[(1E)-2-[4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 50 °C

2.1: boron trioxide; Triisopropyl borate / ethyl acetate / 1 h / 70 °C

2.2: 1 h

3.1: hydrazine hydrate; acetic acid / 3 h / 60 °C

With Triisopropyl borate; caesium carbonate; hydrazine hydrate; acetic acid; boron trioxide; In ethyl acetate; N,N-dimethyl-formamide;