(E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Base Information

Chemical Name:(E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid
CAS No.:1439848-01-7
Molecular Formula:C₁₆H₂₃N₃O₄
Molecular Weight:321.376
Hs Code.:

Synonyms:(E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

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Chemical Property of (E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

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Technology Process of (E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

There total 8 articles about (E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1439853-60-7
methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

: 1439848-01-7
(E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Guidance literature:: methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 1439848-01-7
(E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 12 h / 25 °C

2.1: Dess-Martin periodane / dichloromethane / 0.5 h / 0 °C

3.1: acetic acid / methanol / 0.5 h / 0 °C

4.1: sodium cyanoborohydride / methanol / 12 h / 0 - 25 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

6.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 25 °C

6.2: 0.08 h / 0 °C

With lithium hydroxide monohydrate; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm3018628

Reference yield:

: 1439845-49-4
C₁₇H₂₅N₃O₄

: 1439848-01-7
(E)-4-((4-(4-(aminomethyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoic acid

Guidance literature:: C₁₇H₂₅N₃O₄; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 25 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water; at 0 ℃; for 0.0833333h;
DOI:10.1021/jm3018628