methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

Base Information

Chemical Name:methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate
CAS No.:1439853-60-7
Molecular Formula:C₂₂H₃₃N₃O₆
Molecular Weight:435.521
Hs Code.:

Synonyms:methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

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Chemical Property of methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

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Technology Process of methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

There total 6 articles about methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1310809-24-5
C₉H₁₆N₂O₄

: 156866-52-3
tert-butyl N-(4-formylbenzyl)carbamate

: 1439853-60-7
methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

Guidance literature:: C₉H₁₆N₂O₄; tert-butyl N-(4-formylbenzyl)carbamate; With acetic acid; In methanol; at 0 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 0 - 20 ℃; for 12h;

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 1439853-60-7
methyl (E)-4-((4-(4-((tert-butoxycarbonylamino)methyl)benzylamino)butyl)(hydroxy)amino)-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 12 h / 25 °C

2: Dess-Martin periodane / dichloromethane / 0.5 h / 0 °C

3: acetic acid / methanol / 0.5 h / 0 °C

4: sodium cyanoborohydride / methanol / 12 h / 0 - 25 °C

With sodium cyanoborohydride; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm3018628