tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate
CAS No.:1428308-11-5
Molecular Formula:C₁₉H₂₁N₃O₃S
Molecular Weight:371.46
Hs Code.:

Synonyms:tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

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Chemical Property of tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

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Technology Process of tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

There total 5 articles about tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1428308-12-6
tert-butyl [(3S)-2-oxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

: 1428308-11-5
tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

Guidance literature:: With tetraphosphorus decasulfide; sodium carbonate; In tetrahydrofuran; for 1h; Reflux;
DOI:10.1039/c2md20166f

Reference yield:

: 1258544-93-2
methyl {(2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-nitro-5-phenoxypyridin-3-yl)}propanoate

: 1428308-11-5
tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; zinc / tetrahydrofuran; methanol / 48 h / 60 °C

2: tetraphosphorus decasulfide; sodium carbonate / tetrahydrofuran / 1 h / Reflux

With tetraphosphorus decasulfide; sodium carbonate; ammonium chloride; zinc; In tetrahydrofuran; methanol;
DOI:10.1039/c2md20166f

Reference yield:

: 1258544-92-1
3-bromo-2-nitro-5-phenoxypyridine

: 1428308-11-5
tert-butyl [(3S)-2-thioxo-6-phenoxy-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc; iodine / N,N-dimethyl-formamide

1.2: 12 h / 60 °C

2.1: ammonium chloride; zinc / tetrahydrofuran; methanol / 48 h / 60 °C

3.1: tetraphosphorus decasulfide; sodium carbonate / tetrahydrofuran / 1 h / Reflux

With tetraphosphorus decasulfide; iodine; sodium carbonate; ammonium chloride; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1.1: |Negishi Coupling / 1.2: |Negishi Coupling;
DOI:10.1039/c2md20166f