3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

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Chemical Name:3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one
CAS No.:101527-62-2
Molecular Formula:C₂₈H₂₅N₅O₄
Molecular Weight:495.538
Hs Code.:

Synonyms:3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

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Chemical Property of 3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

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Technology Process of 3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

There total 5 articles about 3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2,2'-anhydro-3'-O-(tolyl-4-sulfonyl)-5'-O-(triphenylmethyl)-2',3'-secouridine

: 101527-62-2
3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 40 ℃; for 40h;
DOI:10.1002/hlca.19950780714

Reference yield: 64.0%

: 101552-16-3
2',3'-di-O-mesyl-5'-O-trityl-2',3'-seco-uridine

: 101527-62-2
3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

Guidance literature:: With lithium azide; In N,N-dimethyl-formamide; at 55 ℃; for 3h; Inert atmosphere;
DOI:10.1002/hlca.201300289

Reference yield:

: 6554-10-5
5'-O-trityluridine

: 101527-62-2
3-{[1-azido-3-(triphenylmethoxy)propan-2-yl]oxy}-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate / 1,4-dioxane; water / 2 h / 20 °C / Inert atmosphere; Darkness

2: sodium tetrahydroborate / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 °C / Inert atmosphere

4: lithium azide / N,N-dimethyl-formamide / 3 h / 55 °C / Inert atmosphere

With sodium tetrahydroborate; sodium periodate; lithium azide; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201300289