5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

Base Information

Chemical Name:5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate
CAS No.:1261138-12-8
Molecular Formula:CH₄O₃S*C₁₈H₁₈ClN₅O₃S
Molecular Weight:515.999
Hs Code.:

Synonyms:5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

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Chemical Property of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

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Technology Process of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

There total 11 articles about 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1159610-29-3
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide

: 1261138-12-8
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

Guidance literature:: In methanol; dichloromethane; at 0 ℃; Product distribution / selectivity;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1261138-12-8
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / acetonitrile / 19 h / 80 °C

1.2: 1 h / 0 °C

2.1: phosphorus tribromide / 1,2-dimethoxyethane / 4.5 h / 0 - 60 °C

2.2: 0.5 h / pH 4

3.1: sodium acetate / 1,2-dimethoxyethane / 15 h / Reflux

4.1: dmap / tetrahydrofuran / 1.5 h / Reflux

5.1: zinc; ammonium chloride / methanol / 13 h / 65 °C

6.1: 2-methyl-propan-1-ol / 18 h / Reflux

7.1: dmap / tetrahydrofuran / 18 h / Reflux

8.1: hydrogenchloride / tetrahydrofuran / 1 h / Reflux

9.1: sodium carbonate / water; methanol / 100 °C

10.1: dichloromethane; methanol / 0 °C

With hydrogenchloride; sodium acetate; phosphorus tribromide; sodium carbonate; potassium carbonate; ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; 2-methyl-propan-1-ol; water; acetonitrile;

Reference yield:

: 43214-49-9
2-[N-(4-nitro-phenyl)-hydrazino]-ethanol

: 1261138-12-8
5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: phosphorus tribromide / 1,2-dimethoxyethane / 4.5 h / 0 - 60 °C

1.2: 0.5 h / pH 4

2.1: sodium acetate / 1,2-dimethoxyethane / 15 h / Reflux

3.1: dmap / tetrahydrofuran / 1.5 h / Reflux

4.1: zinc; ammonium chloride / methanol / 13 h / 65 °C

5.1: 2-methyl-propan-1-ol / 18 h / Reflux

6.1: dmap / tetrahydrofuran / 18 h / Reflux

7.1: hydrogenchloride / tetrahydrofuran / 1 h / Reflux

8.1: sodium carbonate / water; methanol / 100 °C

9.1: dichloromethane; methanol / 0 °C

With hydrogenchloride; sodium acetate; phosphorus tribromide; sodium carbonate; ammonium chloride; zinc; dmap; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; 2-methyl-propan-1-ol; water;