Technology Process of 4,5,7,8-TETRAHYDRO-6H-THIENO[2,3-D]AZEPINE-6-CARBOXYLIC ACID, T-BUTYLESTER
There total 9 articles about 4,5,7,8-TETRAHYDRO-6H-THIENO[2,3-D]AZEPINE-6-CARBOXYLIC ACID, T-BUTYLESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine;
With
sodium hydrogencarbonate;
In
water; acetone;
at 0 ℃;
for 0.5h;
di-tert-butyl dicarbonate;
In
water; acetone;
at 20 ℃;
for 14h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 16 h / 15 - 25 °C
2: sodium hydrogencarbonate / tetrahydrofuran / 16 h / 0 - 25 °C
3: sodium hydroxide; water / ethanol / 16 h / 0 - 25 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 0 - 25 °C
5: aluminum (III) chloride / dichloromethane / 1 h / 0 - 25 °C
6: aluminum (III) chloride; tert-butylamine; diborane / dichloromethane / 12 h / 0 - 25 °C
7: trimethylsilyl iodide / dichloromethane / 12 h / 80 °C
8: triethylamine / dichloromethane / 12 h / 25 °C
With
aluminum (III) chloride; oxalyl dichloride; trimethylsilyl iodide; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; tert-butylamine; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; diborane;
In
tetrahydrofuran; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydrogencarbonate / tetrahydrofuran / 16 h / 0 - 25 °C
2: sodium hydroxide; water / ethanol / 16 h / 0 - 25 °C
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 0 - 25 °C
4: aluminum (III) chloride / dichloromethane / 1 h / 0 - 25 °C
5: aluminum (III) chloride; tert-butylamine; diborane / dichloromethane / 12 h / 0 - 25 °C
6: trimethylsilyl iodide / dichloromethane / 12 h / 80 °C
7: triethylamine / dichloromethane / 12 h / 25 °C
With
aluminum (III) chloride; oxalyl dichloride; trimethylsilyl iodide; water; sodium hydrogencarbonate; tert-butylamine; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; diborane;
In
tetrahydrofuran; ethanol; dichloromethane;
