N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

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Chemical Name:N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide
CAS No.:287120-12-1
Molecular Formula:C₁₉H₃₁N₃O₅S
Molecular Weight:413.538
Hs Code.:

Synonyms:N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

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Chemical Property of N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

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Technology Process of N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

There total 13 articles about N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 108-00-9
N,N-dimethylethylenediamine

: 287120-08-5
2-methanesulfonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetic acid

: 287120-12-1
N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

Guidance literature:: 2-methanesulfonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 50 ℃;

N,N-dimethylethylenediamine; In N,N-dimethyl-formamide; at 20 ℃; Further stages.;
DOI:10.1039/b000135j

Reference yield:

: 51794-07-1
2-hydroxy-5-nitrophenylacetic acid

: 287120-12-1
N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 89 percent / conc. H₂SO₄ / 16 h / Heating

2.1: 82 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

3.1: 88 percent / 1,2-dichloro-benzene / 3 h / 180 °C

4.1: KOH; H₂O / methanol / 2 h / Heating

5.1: 0.81 g / 1 h / 20 °C

6.1: 96 percent / MCPBA / CH₂Cl₂ / 2 h / 20 °C

7.1: H₂ / Pd/C / ethanol / 3102.97 Torr

8.1: tetrahydrofuran / -20 °C

9.1: BH₃*DMS / tetrahydrofuran / 20 °C

10.1: 37 percent / tetrahydrofuran / Heating

11.1: 95 percent / NaOH; H₂O / methanol / 20 °C

12.1: CDI / dimethylformamide / 50 °C

12.2: 73 percent / dimethylformamide / 20 °C

With potassium hydroxide; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; 1.1: Esterification / 2.1: Substitution / 3.1: Rearrangement / 4.1: Hydrolysis / 5.1: Methylation / 6.1: Oxidation / 7.1: Reduction / 8.1: Formylation / 9.1: Reduction / 10.1: Acylation / 11.1: Hydrolysis / 12.1: Addition / 12.2: Substitution;
DOI:10.1039/b000135j

Reference yield:

: 155388-58-2
2-hydroxy-5-nitrophenylacetic acid methyl ester

: 287120-12-1
N-[2-(N,N-dimethylamino)ethyl]-2-methanesulphonyl-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 82 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2.1: 88 percent / 1,2-dichloro-benzene / 3 h / 180 °C

3.1: KOH; H₂O / methanol / 2 h / Heating

4.1: 0.81 g / 1 h / 20 °C

5.1: 96 percent / MCPBA / CH₂Cl₂ / 2 h / 20 °C

6.1: H₂ / Pd/C / ethanol / 3102.97 Torr

7.1: tetrahydrofuran / -20 °C

8.1: BH₃*DMS / tetrahydrofuran / 20 °C

9.1: 37 percent / tetrahydrofuran / Heating

10.1: 95 percent / NaOH; H₂O / methanol / 20 °C

11.1: CDI / dimethylformamide / 50 °C

11.2: 73 percent / dimethylformamide / 20 °C

With potassium hydroxide; sodium hydroxide; dimethylsulfide borane complex; water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; 1.1: Substitution / 2.1: Rearrangement / 3.1: Hydrolysis / 4.1: Methylation / 5.1: Oxidation / 6.1: Reduction / 7.1: Formylation / 8.1: Reduction / 9.1: Acylation / 10.1: Hydrolysis / 11.1: Addition / 11.2: Substitution;
DOI:10.1039/b000135j