3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

Base Information

Chemical Name:3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride
CAS No.:1334711-98-6
Molecular Formula:C₂₁H₂₁ClN₄*ClH
Molecular Weight:401.338
Hs Code.:

Synonyms:3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

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Chemical Property of 3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

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Technology Process of 3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

There total 6 articles about 3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 2417-90-5
bromopropionitrile

: 1334711-87-3
1-(4-chlorophenyl)-3-piperidin-4-yl-1H-pyrrolo[2,3-c]pyridine trifluoroacetate

: 1334711-98-6
3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

Guidance literature:: bromopropionitrile; 1-(4-chlorophenyl)-3-piperidin-4-yl-1H-pyrrolo[2,3-c]pyridine trifluoroacetate; With potassium carbonate; In N,N-dimethyl-formamide;

With hydrogenchloride; In methanol;

Reference yield:

: 271-29-4
6-azaindole

: 1334711-98-6
3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / Reflux

2: cyclohexene / palladium 10% on activated carbon / ethanol / 0.42 h / 150 °C / Microwave irradiation

3: potassium phosphate / copper(l) iodide; N,N-dimethylethylenediamine / toluene / 72 h / 110 °C

4: dichloromethane / 2 h

5: potassium carbonate / N,N-dimethyl-formamide

With potassium phosphate; potassium carbonate; potassium hydroxide; cyclohexene; copper(l) iodide; palladium 10% on activated carbon; N,N-dimethylethylenediamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Buchwald-Hartwig Reaction;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1334711-98-6
3-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridine-3-yl]piperidin-1-yl}propanenitrile hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / Reflux

2: cyclohexene / palladium 10% on activated carbon / ethanol / 0.42 h / 150 °C / Microwave irradiation

3: potassium phosphate / copper(l) iodide; N,N-dimethylethylenediamine / toluene / 72 h / 110 °C

4: dichloromethane / 2 h

5: potassium carbonate / N,N-dimethyl-formamide

With potassium phosphate; potassium carbonate; potassium hydroxide; cyclohexene; copper(l) iodide; palladium 10% on activated carbon; N,N-dimethylethylenediamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Buchwald-Hartwig Reaction;