rac-methyl 3-(benzylamino)-3-phenylpropanoate

Base Information

• Chemical Name: rac-methyl 3-(benzylamino)-3-phenylpropanoate
• CAS No.: 150931-58-1
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 150931-58-1.mol

Synonyms:rac-methyl 3-(benzylamino)-3-phenylpropanoate

Chemical Property of rac-methyl 3-(benzylamino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-methyl 3-(benzylamino)-3-phenylpropanoate

There total 6 articles about rac-methyl 3-(benzylamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 3-(N-benzoyloxy-N-benzylamino)-3-phenylpropionate (150931-43-4) → rac-methyl 3-(benzylamino)-3-phenylpropanoate (150931-58-1)

Guidance literature:

With acetic acid; zinc; at 60 ℃; for 1h;

DOI:10.1246/bcsj.73.2423

Reference yield: 73.0%

N-Benzylidenebenzylamine N-oxide (3376-26-9) + ketene t-butyldimethylsilyl methyl acetal (77086-38-5) + benzoyl chloride (98-88-4) → rac-methyl 3-(benzylamino)-3-phenylpropanoate (150931-58-1)

Guidance literature:

N-Benzylidenebenzylamine N-oxide; benzoyl chloride; In dichloromethane; at 20 ℃; for 0.0519444h; Flow reactor;

ketene t-butyldimethylsilyl methyl acetal; In dichloromethane; at 20 - 30 ℃; for 0.13h; Flow reactor;

With zinc; In acetic acid;

DOI:10.1055/s-0039-1691601

Reference yield:

C17H17NO2 (1196876-22-8) → rac-methyl 3-(benzylamino)-3-phenylpropanoate (150931-58-1)

Guidance literature:

With trichlorosilane; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; at -10 ℃; for 10h; stereoselective reaction;

DOI:10.1039/c3ob40430g

upstream raw materials:

methyl 3-(N-benzoyloxy-N-benzylamino)-3-phenylpropionate

N-Benzylidenebenzylamine N-oxide

C₁₇H₁₇NO₂

ketene t-butyldimethylsilyl methyl acetal

Downstream raw materials:

β-phenyl β-(benzylamino) propionic acid

(S)-N-benzyl-β³-homophenylglycine

(R)-N-benzyl-β³-homophenylglycine

1-benzyl-4-phenyl-2-azetidinone