N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

Base Information

Chemical Name:N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide
CAS No.:1190098-06-6
Molecular Formula:C₂₃H₁₉N₃O₄S₂
Molecular Weight:465.554
Hs Code.:

Synonyms:N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

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Chemical Property of N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

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Technology Process of N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

There total 6 articles about N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1190097-05-2
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

: 1190098-06-6
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

Guidance literature:: With Lawessons reagent; In 1,4-dioxane; toluene; at 110 ℃; for 16h;

Reference yield:

: 4498-67-3,877309-58-5
2H-indazole-3-carboxylic acid

: 1190098-06-6
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation

3.1: sodium hydroxide / 1,4-dioxane / 20 °C

3.2: Amberlite-H⁺

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: Lawessons reagent / toluene; 1,4-dioxane / 16 h / 110 °C

With Lawessons reagent; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1190098-68-0
methyl 1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxylate

: 1190098-06-6
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 1,4-dioxane / 20 °C

1.2: Amberlite-H⁺

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: Lawessons reagent / toluene; 1,4-dioxane / 16 h / 110 °C

With Lawessons reagent; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;