N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

Base Information

Chemical Name:N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide
CAS No.:1190097-05-2
Molecular Formula:C₂₃H₁₉N₃O₅S
Molecular Weight:449.487
Hs Code.:

Synonyms:N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

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Chemical Property of N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

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Technology Process of N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

There total 4 articles about N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 14268-66-7
benzo[1,3]dioxolo-5-ylamine

: 50264-77-2
1-(4-methanesulfonyl-benzyl)-1H-indazole-3-carboxylic acid

: 1190097-05-2
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 4498-67-3,877309-58-5
2H-indazole-3-carboxylic acid

: 1190097-05-2
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation

3.1: sodium hydroxide / 1,4-dioxane / 20 °C

3.2: Amberlite-H⁺

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 43120-28-1
methyl 1H-indazole-3-carboxylate

: 1190097-05-2
N-(benzo[d][1,3]dioxol-5-yl)-1-(4-(methylsulfonyl)benzyl)-1H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation

2.1: sodium hydroxide / 1,4-dioxane / 20 °C

2.2: Amberlite-H⁺

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;