3-Pyrrolidinecarboxylic acid, 4-(4-fluorophenyl)-5-(hydroxymethyl)-1-(phenylmethyl)-, 1,1-dimethylethyl ester, (3R,4S,5R)-rel-

Base Information

Chemical Name:3-Pyrrolidinecarboxylic acid, 4-(4-fluorophenyl)-5-(hydroxymethyl)-1-(phenylmethyl)-, 1,1-dimethylethyl ester, (3R,4S,5R)-rel-
CAS No.:369593-37-3
Molecular Formula:C₂₃H₂₈FNO₃
Molecular Weight:385.479
Hs Code.:

Synonyms:isobutyl (3S,4R,5S)-1-benzyl-4-(4-fluorophenyl)-5-(hydroxymethyl)pyrrolidine-3-carboxylate

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Chemical Property of 3-Pyrrolidinecarboxylic acid, 4-(4-fluorophenyl)-5-(hydroxymethyl)-1-(phenylmethyl)-, 1,1-dimethylethyl ester, (3R,4S,5R)-rel-

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Technology Process of 3-Pyrrolidinecarboxylic acid, 4-(4-fluorophenyl)-5-(hydroxymethyl)-1-(phenylmethyl)-, 1,1-dimethylethyl ester, (3R,4S,5R)-rel-

There total 7 articles about 3-Pyrrolidinecarboxylic acid, 4-(4-fluorophenyl)-5-(hydroxymethyl)-1-(phenylmethyl)-, 1,1-dimethylethyl ester, (3R,4S,5R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 369593-36-2
isobutyl (3S,6S,7R,7aR)-7-(4-fluorophenyl)-3-phenyl-5-oxo-tetrahydro-1H,3H-pyrrolo[1,2-c]oxazole-6-carboxylate

: 369593-37-3
isobutyl (3S,4R,5S)-1-benzyl-4-(4-fluorophenyl)-5-(hydroxymethyl)pyrrolidine-3-carboxylate

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 1.5h;
DOI:10.1016/S0040-4039(01)01096-6

Reference yield: 44.0%

: 369593-36-2
isobutyl (3S,6S,7R,7aR)-7-(4-fluorophenyl)-3-phenyl-5-oxo-tetrahydro-1H,3H-pyrrolo[1,2-c]oxazole-6-carboxylate

: 369593-37-3
isobutyl (3S,4R,5S)-1-benzyl-4-(4-fluorophenyl)-5-(hydroxymethyl)pyrrolidine-3-carboxylate

: 503552-80-5
(2S,3R,4S)-1-benzyl-3-(4-fluorophenyl)pyrrolidine-2,4-bismethanol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1002/1099-0690(200211)2002:21<3543::AID-EJOC3543>3.0.CO;2-0

Reference yield:

: isobutyl (3S,7aR)-5-oxo-3-phenyl-6-(phenylseleno)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazole-6-carboxylate

: 369593-37-3
isobutyl (3S,4R,5S)-1-benzyl-4-(4-fluorophenyl)-5-(hydroxymethyl)pyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂O₂ / CH₂Cl₂ / 0.5 h / 0 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: copper iodide / tetrahydrofuran / 0.5 h / -25 °C

2.3: 97 percent / tetrahydrofuran / 2 h / -78 °C

3.1: 44 percent / borane*tetrahydrofuran / tetrahydrofuran / 1.5 h / 20 °C

With n-butyllithium; borane-THF; dihydrogen peroxide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/1099-0690(200211)2002:21<3543::AID-EJOC3543>3.0.CO;2-0