369593-36-2

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 369593-35-1 isobutyl (3S,7aR)-5-oxo-3-phenyl-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazole-6-carboxylate 
• 543-27-1 isobutyl chloroformate 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 

Downstream Products

• 369593-37-3 isobutyl (3S,4R,5S)-1-benzyl-4-(4-fluorophenyl)-5-(hydroxymethyl)pyrrolidine-3-carboxylate 
• 503552-80-5 (2S,3R,4S)-1-benzyl-3-(4-fluorophenyl)pyrrolidine-2,4-bismethanol 
• 201855-60-9 (3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanol 
• 369593-39-5 isobutyl (3S,4R)-1-benzyl-4-(4-fluorophenyl)piperidine-3-carboxylate 
• 369593-38-4 isobutyl (3S,4R,5S)-1-benzyl-5-chloro-4-(4-fluorophenyl)piperidine-3-carboxylate 

Relevant academic research and scientific papers

A formal synthesis of (-)-paroxetine by enantioselective ring enlargement of a trisubstituted prolinol

A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (-)-paroxetine. The substituted piperidine ring precursor of (-)-paroxetine was generated by means of a stereoselective ring expansion of prolinol. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).

Ring expansion: Formal total synthesis of (-)-paroxetine

A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (-)-paroxetine. A stereoselective ring expansion of prolinol generated the substituted piperidine ring precursor of (-)-paroxetine.