2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester
CAS No.:886228-73-5
Molecular Formula:C₁₇H₂₅FO₃Si
Molecular Weight:324.468
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

Synonyms:2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

Chemical Property:

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

There total 4 articles about 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 886228-59-7
3-(4-fluoro-phenyl)-2-hydroxymethyl-acrylic acid methyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 886228-73-5
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1055/s-2006-932489

Reference yield:

: 1010396-60-7
methyl (Z)-4-(bromomethyl)-3-(4-fluorophenyl)-2-propenoate

: 886228-73-5
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / acetonitrile / Heating

2: aq. HCl / methanol

3: 100 percent / imidazole / dimethylformamide

With 1H-imidazole; hydrogenchloride; triethylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2006-932489

Reference yield:

: 3-(4-fluoro-phenyl)-2-formyloxymethyl-acrylic acid methyl ester

: 886228-73-5
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / methanol

2: 100 percent / imidazole / dimethylformamide

With 1H-imidazole; hydrogenchloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-932489