N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

Base Information

Chemical Name:N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide
CAS No.:1342815-18-2
Molecular Formula:C₂₀H₂₅ClN₄O₂
Molecular Weight:388.897
Hs Code.:

Synonyms:N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

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Chemical Property of N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

Chemical Property:

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Technology Process of N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

There total 7 articles about N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 500-22-1
3-pyridinecarboxaldehyde

: 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)-benzamide hydrochloride

: 1342815-18-2
N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

Guidance literature:: With acetic acid; sodium cyanoborohydride; In methanol; at 60 ℃; for 5h;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1342815-18-2
N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 6 h / 120 °C

3.1: triphenylphosphine / tetrahydrofuran / 2 h / Reflux

3.2: 3 h / Reflux

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: acetic acid / sodium cyanoborohydride / methanol / 5 h / 60 °C

With hydrogenchloride; sodium azide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium cyanoborohydride; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 1342815-18-2
N-((1-(pyridin-3-ylmethyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / methanol / 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 6 h / 120 °C

4.1: triphenylphosphine / tetrahydrofuran / 2 h / Reflux

4.2: 3 h / Reflux

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

7.1: acetic acid / sodium cyanoborohydride / methanol / 5 h / 60 °C

With hydrogenchloride; sodium azide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium cyanoborohydride; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;