2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

Base Information

Chemical Name:2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate
CAS No.:325708-72-3
Molecular Formula:C₂₆H₂₆N₁₀O₇
Molecular Weight:590.555
Hs Code.:

Synonyms:2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

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Chemical Property of 2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

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Technology Process of 2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

There total 5 articles about 2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4,4'-azidobenzoic anhydride

: 325708-69-8
N²-[(dimethylamino)methylene]-5,6,7,8-tetrahydro-6-(hydroxymethyl)-5-{[2-(4-nitrophenyl)ethoxy]carbonyl}pterin

: 325708-72-3
2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

Guidance literature:: With dmap; In pyridine; at 20 ℃; for 25h;
DOI:10.1002/1522-2675(20001004)83:10<2738::AID-HLCA2738>3.0.CO;2-A

Reference yield: 56.0%

: 6427-66-3
4-azidobenzoic acid

: 325708-69-8
N²-[(dimethylamino)methylene]-5,6,7,8-tetrahydro-6-(hydroxymethyl)-5-{[2-(4-nitrophenyl)ethoxy]carbonyl}pterin

: 325708-72-3
2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; at 20 ℃; for 18h;
DOI:10.1002/1522-2675(20001004)83:10<2738::AID-HLCA2738>3.0.CO;2-A

Reference yield:

: 712-29-8
6-(hydroxymethyl)pterin

: 325708-72-3
2-(4-nitrophenyl)ethyl 6-{[(4-azidobenzoyl)oxy]methyl}-2-{[(dimethylamino)methylene]amino}-3,4,5,6,7,8-hexahydro-4-oxopteridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / PtO₂ / trifluoroacetic acid / 4 h / 20 °C

2: 86 percent / pyridine / 12 h / 20 °C

3: 57 percent / dimethylformamide / 2.5 h / 20 °C

4: 56 percent / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide HCl; N,N-dimethylpyridin-4-amine / pyridine / 18 h / 20 °C

With pyridine; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In pyridine; N,N-dimethyl-formamide; trifluoroacetic acid; 1: Hydrogenation / 2: Acylation / 3: Condensation / 4: Acylation;
DOI:10.1002/1522-2675(20001004)83:10<2738::AID-HLCA2738>3.0.CO;2-A