(Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

Base Information

Chemical Name:(Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide
CAS No.:1393367-73-1
Molecular Formula:C₄₄H₄₉OP
Molecular Weight:624.846
Hs Code.:

Synonyms:(Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

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Chemical Property of (Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

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Technology Process of (Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

There total 3 articles about (Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1393367-72-0
(Rp)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1-oxo-1H-phosphindol-5-yl trifluoromethanesulfonate

: 1393367-71-9
(E)-2-(5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1393367-73-1
(Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

Guidance literature:: With PdCl₂(SPhos)2; caesium carbonate; In tetrahydrofuran; water; at 85 ℃; for 18h;
DOI:10.1002/anie.201202024

Reference yield:

: (Z)-4,5-bis[(4’,4’,5’,5’-tetramethyl-[1’,3’,2’]-dioxaborolan-2’-yl)]oct-4-ene

: 1393367-73-1
(Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 1.5 h / 85 °C

2: PdCl₂(SPhos)2; caesium carbonate / tetrahydrofuran; water / 18 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; PdCl₂(SPhos)2; sodium carbonate; caesium carbonate; In tetrahydrofuran; ethanol; water; toluene; 1: Suzuki coupling / 2: Suzuki coupling;
DOI:10.1002/anie.201202024

Reference yield:

: 5-hydroxy-1-menthyl-1H-phosphindole 1-oxide

: 1393367-73-1
(Rp)-5-((Z)-5-(benzo[c]phenanthren-2-yl)oct-4-en-4-yl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-1H-phosphindole 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere

2: PdCl₂(SPhos)2; caesium carbonate / tetrahydrofuran; water / 18 h / 85 °C

With PdCl₂(SPhos)2; caesium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1002/anie.201202024