(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

Base Information

Chemical Name:(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one
CAS No.:1026790-41-9
Molecular Formula:C₂₀H₁₆F₂N₆O₂
Molecular Weight:410.383
Hs Code.:

Synonyms:(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

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Chemical Property of (R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

Chemical Property:

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Technology Process of (R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

There total 16 articles about (R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911826-26-1
(R)-2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

: 1026790-41-9
(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 20 ℃; for 17h;

Reference yield:

: 791043-28-2
8-fluorochroman-4-amine

: 1026790-41-9
(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: novozyme 435 / tert-butyl methyl ether / 2 h / Heating / reflux; Enzymatic reaction; Resolution of racemate

2: hydrogenchloride; ethanol; water / 4 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

4: potassium carbonate / acetonitrile / 3 h / 65 °C

5: hydrogen / nickel / tetrahydrofuran / 2 h / 20 °C

6: tetrahydrofuran / 18 h

7: triethylsilane; trifluoroacetic acid / 17 h / 20 °C

With hydrogenchloride; triethylsilane; ethanol; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; novozyme 435; nickel; In tetrahydrofuran; tert-butyl methyl ether; acetonitrile;

Reference yield:

: 911826-24-9
N₁-(2,4-dimethoxybenzyl)-5-fluorobenzene-1,2-diamine

: 1026790-41-9
(R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 3 h / 65 °C

2: hydrogen / nickel / tetrahydrofuran / 2 h / 20 °C

3: tetrahydrofuran / 18 h

4: triethylsilane; trifluoroacetic acid / 17 h / 20 °C

With triethylsilane; hydrogen; potassium carbonate; trifluoroacetic acid; nickel; In tetrahydrofuran; acetonitrile;