791043-28-2

Basic information

• Product Name: 8-fluorochroman-4-amine
• Synonyms: 8-fluorochroman-4-amine;(8-Fluoro-3,4-dihydro-2H-chromen-4-yl)amine;8-fluoro-3,4-dihydro-2H-chroMen-4-aMine
• CAS NO: 791043-28-2
• Molecular Formula: C9H10FNO
• Molecular Weight: 167.1802032
• Mol File: 791043-28-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 228℃
• Flash Point: 92℃
• Appearance: /
• Density: 1.201
• Vapor Pressure: 0.0743mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 8-fluorochroman-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-fluorochroman-4-amine(791043-28-2)
• EPA Substance Registry System: 8-fluorochroman-4-amine(791043-28-2)

Safety Data

• Hazardous Substances Data: 791043-28-2(Hazardous Substances Data)

Usage

General Description

8-Fluorochroman-4-amine is a chemical compound that falls under the category of organic compounds known as benzopyrans. These are organic compounds containing a benzene ring fused to a pyran ring. Commonly, 8-Fluorochroman-4-amine is used in the synthesis of other more complex chemicals or as intermediates in the production of pharmaceuticals or other fine chemicals. It might exhibit bioactive properties, but this information is not widely available, and its potential implications in health have not been thoroughly explored. Its exact properties such as boiling point, melting point, and specific gravity can depend on the particular formulation of the compound. Due to its chemical nature, handling of 8-Fluorochroman-4-amine must be done properly following proper safety procedures.

InChI:InChI=1/C9H10FNO/c10-7-3-1-2-6-8(11)4-5-12-9(6)7/h1-3,8H,4-5,11H2

Upstream product

• 2967-72-8 3-(2-fluorophenoxy)propanoic acid 
• 111141-00-5 8-fluoro-2,3-dihydro-4-H-1-benzopyran-4-one 
• 367-12-4 2-fluorophenol 
• 1018978-81-8 C₉H₈FNO₂ 

Downstream Products

• 1003887-62-4 (S)-8-fluorochroman-4-amine 
• 911826-29-4 (R)-N-(8-fluorochroman-4-yl)-2-methoxyacetamide 
• 911826-26-1 (R)-2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one 
• 911826-25-0 (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine 
• 1026790-40-8 (R)-N₂-(2-(2,4-dimethoxybenzylamino)-4-fluorophenyl)-N₄-(8-fluorochroman-4-yl)pyrimidine-2,4,5-triamine 
• 1026790-41-9 (R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one 
• 750571-31-4 (R)-8-fluorochroman-4-amine 

Relevant articles and documents

2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors

A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was identified incorporating a chroman-based functional group. Compound 24 shows excellent kinase activity, good oral bioavailability and demonstrates efficacy in an acute mechanistic mouse model through inhibition of interleukin-2 (IL-2) induced interferon-γ (INF-γ) production.

7-Substituted Purine Derivatives for Immunosuppression

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III:

PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION

The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas ( I ) and ( II ).