ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate

Base Information

• Chemical Name: ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate
• CAS No.: 77132-51-5
• Molecular Formula: C₁₈H₁₈N₂O₂S₂
• Molecular Weight: 358.485

Synonyms:ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate

Chemical Property of ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate

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Technology Process of ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate

There total 1 articles about ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(2-amino-4,5-dimethylthiophen-3-yl)(phenyl)methanone (42024-93-1) + ethyl 2-isothiocyanatoacetate (24066-82-8) → ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate (77132-51-5)

Guidance literature:

In benzene; for 20h; Heating;

DOI:10.1248/cpb.28.3172

Reference yield: 83.0%

ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate (77132-51-5) + methyl iodide (74-88-4) → (5,6-Dimethyl-2-methylsulfanyl-4-phenyl-4H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester; hydriodide (77132-58-2)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1248/cpb.28.3172

Reference yield: 75.0%

ethyl 5,6-dimethyl-4-phenyl-2-thioxo-2,3-dihydrothieno<2,3-d>pyrimidine-3-acetate (77132-51-5) → (5,6-Dimethyl-4-phenyl-2-thioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester (77132-47-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; chloroform; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.28.3172

upstream raw materials:

(2-amino-4,5-dimethylthiophen-3-yl)(phenyl)methanone

ethyl 2-isothiocyanatoacetate

Downstream raw materials:

(5,6-Dimethyl-4-phenyl-2-thioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester

(5,6-Dimethyl-2-methylsulfanyl-4-phenyl-4H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester; hydriodide

2-amino-5,6-dimethyl-4-phenylthieno<2,3-d>pyrimidine

6,7-dimethyl-5-phenyl-1,2,3,5-tetrahydroimidazo<1,2-a>thieno<2,3-d>pyrimidin-2-one

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