2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester
CAS No.:289708-00-5
Molecular Formula:C₂₈H₄₃N₃O₉
Molecular Weight:565.664
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-phenyl-propionic acid 2-<i>tert</i>-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

Synonyms:2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

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Technology Process of 2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

There total 3 articles about 2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 39687-95-1
isocyanoacetic acid methyl ester

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 289708-00-5
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(02)00728-1

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 289708-00-5
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / BH₃*Me₂S

2: 95 percent / CH₂Cl₂ / 24 h / 20 °C

With dimethylsulfide borane complex; In dichloromethane; 2: Swern oxidation / 3: Passerini reaction;
DOI:10.1016/S0040-4039(02)00728-1

Reference yield:

: 79069-14-0
(S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutan-1-ol

: 289708-00-5
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 24 h / 20 °C

In dichloromethane; 1: Swern oxidation / 2: Passerini reaction;
DOI:10.1016/S0040-4039(02)00728-1