2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

Base Information

Chemical Name:2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide
CAS No.:749247-36-7
Molecular Formula:C₁₈H₂₁NO₄
Molecular Weight:315.369
Hs Code.:

2-(4-hydroxy-3-methoxy-phenyl)-<i>N</i>-(2-hydroxy-2-phenyl-ethyl)-<i>N</i>-methyl-acetamide

Synonyms:2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

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Technology Process of 2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

There total 1 articles about 2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 68579-60-2,6589-55-5
2-(methylamino)-1-phenylethanol

: 306-08-1
Homovanillic acid

: 749247-36-7
2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1055/s-2004-825618

Reference yield: 63.0%

: 749247-36-7
2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

: 749247-37-8
7-hydroxy-8-methoxy-3-methyl-5-phenyl-1,3,4,5-tetrahydro-benzo[d]azepin-2-one

Guidance literature:: With methanesulfonic acid; for 3h;
DOI:10.1055/s-2004-825618

Reference yield:

: 749247-36-7
2-(4-hydroxy-3-methoxy-phenyl)-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-acetamide

: C-(8-methoxy-7-methoxymethoxy-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-2-yl)-methylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 63 percent / MsOH / 3 h

2.1: 95 percent / NaH

3.1: 51 percent / DIBALH / tetrahydrofuran; toluene / 18 h / -78 - 20 °C

4.1: methanol; aq. phosphate buffer / 72 h / 20 °C / pH 7.2

4.2: 0.44 g / KHMDS / tetrahydrofuran; toluene / 0.33 h / -78 °C

5.1: LiAlH₄; H₂O / tetrahydrofuran / 1.25 h

With lithium aluminium tetrahydride; methanesulfonic acid; water; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; methanol; phosphate buffer; toluene;
DOI:10.1055/s-2004-825618