2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

Base Information

Chemical Name:2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde
CAS No.:1383128-83-3
Molecular Formula:C₁₈H₁₄INO₃
Molecular Weight:419.219
Hs Code.:

Synonyms:2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

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Chemical Property of 2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

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Technology Process of 2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

There total 2 articles about 2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1383129-63-2
1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

: 1383128-83-3
2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

Guidance literature:: With iodine; In acetone; at 20 ℃; Inert atmosphere;
DOI:10.1039/c2cc32783j

Reference yield:

: 1383129-40-5
N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(o-tolyl)propiolamide

: 1383128-83-3
2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: Iodine monochloride / dichloromethane / -78 °C / Inert atmosphere

2: iodine / acetone / 20 °C / Inert atmosphere

With iodine; Iodine monochloride; In dichloromethane; acetone; 1: Larock iodocyclization reaction;
DOI:10.1039/c2cc32783j

Reference yield:

: 1383128-83-3
2-(3-iodo-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

: C₁₈H₁₄INO₃

: 1383129-03-0
(6aS,10aR)-2-iodo-1-(o-tolyl)-6a,7-dihydropyrrolo[2,1-i]indole-3,6,8(5H)-trione

Guidance literature:: With (5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In toluene; at 25 ℃; for 50h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc32783j