1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

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Chemical Name:1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione
CAS No.:1383129-63-2
Molecular Formula:C₂₂H₂₄INO₄
Molecular Weight:493.341
Hs Code.:

Synonyms:1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

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Chemical Property of 1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

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Technology Process of 1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

There total 2 articles about 1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1383129-40-5
N-(2,2-diethoxyethyl)-N-(4-methoxyphenyl)-3-(o-tolyl)propiolamide

: 1383129-63-2
1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

Guidance literature:: With Iodine monochloride; In dichloromethane; at -78 ℃; Inert atmosphere;
DOI:10.1039/c2cc32783j

Reference yield:

: 645-36-3
2,2-diethoxy-ethanamine

: 1383129-63-2
1-(2,2-diethoxyethyl)-3-iodo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 40 h / 80 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

3: Iodine monochloride / dichloromethane / -78 °C / Inert atmosphere

With dmap; copper(l) iodide; Iodine monochloride; potassium carbonate; dicyclohexyl-carbodiimide; L-proline; In dichloromethane; dimethyl sulfoxide; 3: Larock iodocyclization reaction;
DOI:10.1039/c2cc32783j