4-Chloro-5-methyl-imidazo[5,1-F][1,2,4]triazine

Base Information

• Chemical Name: 4-Chloro-5-methyl-imidazo[5,1-F][1,2,4]triazine
• CAS No.: 865444-79-7
• Molecular Formula: C₆H₅ClN₄
• Molecular Weight: 168.585
• DSSTox Substance ID: DTXSID801246487
• Mol file: 865444-79-7.mol

Synonyms:865444-79-7;4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE;4-Chloro-5-methylimidazo[5,1-f][1,2,4]triazine;4-Chloro-5-methylimidazo[1,5-f][1,2,4]triazine;4-CHLORO-5-METHYLIMIDAZO[4,3-F][1,2,4]TRIAZINE;SCHEMBL5988582;Imidazo[5,1-f][1,2,4]triazine, 4-chloro-5-methyl-;KUQZKUDARXMPQV-UHFFFAOYSA-N;DTXSID801246487;AKOS006285991;PB12493;PS-17364;CS-0057447;P10555;EN300-1601421;Z1198176317

Chemical Property of 4-Chloro-5-methyl-imidazo[5,1-F][1,2,4]triazine

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 168.0202739
• Heavy Atom Count: 11
• Complexity: 154

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5-methylimidazo[1,5-f][1,2,4]triazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C2C(=NC=NN2C=N1)Cl

Technology Process of 4-Chloro-5-methyl-imidazo[5,1-F][1,2,4]triazine

There total 1 articles about 4-Chloro-5-methyl-imidazo[5,1-F][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5-methyl-3H,4H-imidazo[4,3-f][1,2,4]triazin-4-one (865444-78-6) → 4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine (865444-79-7)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-aniline; at 20 - 140 ℃; for 1h; Heating / reflux;

Reference yield: 31.0%

4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine (865444-79-7) + N-methyl-N-(4-methoxyphenyl)amine (5961-59-1) → N-(4-methoxyphenyl)-N,5-dimethylimidazo[5,1-f][1,2,4]triazin-4-amine (1023758-34-0)

Guidance literature:

toluene-4-sulfonic acid; In isopropyl alcohol; at 20 - 90 ℃; for 2h;

Reference yield: 20.0%

4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine (865444-79-7) + 3.5-dimethoxyaniline (10272-07-8) → N-(3,5-dimethoxyphenyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4-amine (1023758-32-8)

Guidance literature:

toluene-4-sulfonic acid; In isopropyl alcohol; at 20 - 90 ℃; for 0.5h;

upstream raw materials:

5-methyl-3H,4H-imidazo[4,3-f][1,2,4]triazin-4-one

Downstream raw materials:

N-(3,5-dimethoxyphenyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4-amine

N-(4-methoxyphenyl)-N,5-dimethylimidazo[5,1-f][1,2,4]triazin-4-amine