(R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide

Base Information

• Chemical Name: (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide
• CAS No.: 1204313-93-8
• Molecular Formula: C₂₈H₂₅F₃N₂O₄S
• Molecular Weight: 542.579
• Mol file: 1204313-93-8.mol

Synonyms:(R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide

Chemical Property of (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide

There total 4 articles about (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-trifluoromethylphenyl)propyl 4-methylphenylsulfonate + (R)-N-(1-naphthalen-1-yl-ethyl)-4-nitro-benzenesulfonamide (1204313-92-7) → (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide (1204313-93-8)

Guidance literature:

With potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In 4-methyl-2-pentanone; at 85 - 90 ℃; for 15h; Product distribution / selectivity;

Reference yield:

3-[3-(trifluoromethyl)phenyl]propan-1-ol (78573-45-2) → (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide (1204313-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dmap / dichloromethane / 15 h / 25 - 40 °C

2.1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / 4-methyl-2-pentanone / 1 h / 20 °C

2.2: 15 h / 85 - 90 °C

With potassium carbonate; triethylamine; dmap; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; 4-methyl-2-pentanone;

Reference yield:

3-(3-trifluoromethylphenyl)propanoic acid (585-50-2) → (R)-4-nitro-N-(1-naphthalen-1-yl-ethyl)-N-[3-(3-trifluoromethyl-phenyl)-propyl]-benzene sulphonamide (1204313-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / toluene / 40 - 85 °C

2.1: triethylamine / dmap / dichloromethane / 15 h / 25 - 40 °C

3.1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / 4-methyl-2-pentanone / 1 h / 20 °C

3.2: 15 h / 85 - 90 °C

With dimethylsulfide borane complex; potassium carbonate; triethylamine; dmap; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; 4-methyl-2-pentanone; toluene;

upstream raw materials:

(R)-N-(1-naphthalen-1-yl-ethyl)-4-nitro-benzenesulfonamide

(R)-1-(1-Naphthyl)ethylamine

4-Nitrobenzenesulfonyl chloride

3-[3-(trifluoromethyl)phenyl]propan-1-ol

Downstream raw materials:

cinacalcet

cinacalcet hydrochloride

Refernces

• 1、 -. "PROCESS FOR PREPARING CINACALCET AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF". Page/Page column 42. . Retrieved 2010/04/03.