(R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate
• CAS No.: 1219799-68-4
• Molecular Formula: C₃₄H₄₄N₂O₈S₂
• Molecular Weight: 672.864

Synonyms:(R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate

Chemical Property of (R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate

There total 1 articles about (R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-tert-butyl 4-(((S)-1-hydroxy-3-phenylpropan-2-ylamino)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1219799-61-7) + p-toluenesulfonyl chloride (98-59-9) → (R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate (1219799-68-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.01.035

Reference yield: 87.0%

(R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate (1219799-68-4) → (R)-tert-butyl 4-((N-((S)-1-azido-3-phenylpropan-2-yl)-4-methylphenylsulfonamido)methyl)-2,2-dimethyloxazolidine-3-carboxylate (1219799-77-5)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.01.035

Reference yield:

(R)-tert-butyl 2,2-dimethyl-4-((4-methyl-N-((S)-1-phenyl-3-(tosyloxy)propan-2-yl)phenylsulfonamido)methyl)oxazolidine-3-carboxylate (1219799-68-4) → (S)-2-(N-((R)-2-(tert-butoxycarbonylamino)-3-hydroxypropyl) 4-methylphenylsulfonamido)-3-phenylpropyl 4-methylbenzenesulfonate (1219799-72-0)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 0 ℃; for 3h;

DOI:10.1016/j.tetlet.2010.01.035

upstream raw materials:

(R)-tert-butyl 4-(((S)-1-hydroxy-3-phenylpropan-2-ylamino)methyl)-2,2-dimethyloxazolidine-3-carboxylate

p-toluenesulfonyl chloride

Downstream raw materials:

(S)-2-(N-((R)-2-(tert-butoxycarbonylamino)-3-hydroxypropyl) 4-methylphenylsulfonamido)-3-phenylpropyl 4-methylbenzenesulfonate

(R)-tert-butyl 4-((N-((S)-1-azido-3-phenylpropan-2-yl)-4-methylphenylsulfonamido)methyl)-2,2-dimethyloxazolidine-3-carboxylate

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