4-ETHOXY-3-(TRIFLUOROMETHYL)BENZENEBORONIC ACID

Base Information

• Chemical Name: 4-ETHOXY-3-(TRIFLUOROMETHYL)BENZENEBORONIC ACID
• CAS No.: 871329-83-8
• Molecular Formula: C9H10 B F3 O3
• Molecular Weight: 233.983
• Hs Code.: 2931900090
• Mol file: 871329-83-8.mol

Synonyms:Boronicacid, [4-ethoxy-3-(trifluoromethyl)phenyl]- (9CI);(4-Ethoxy-3-trifluoromethylphenyl)boronic acid

Chemical Property of 4-ETHOXY-3-(TRIFLUOROMETHYL)BENZENEBORONIC ACID

Chemical Property:

• Vapor Pressure: 5.24E-05mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 333.9°C at 760 mmHg
• PKA: 7.95±0.10(Predicted)
• Flash Point: 155.8°C
• PSA: 49.69000
• Density: 1.31g/cm³
• LogP: 0.78390
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Ethoxy-3-trifluoromethylphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 4-ETHOXY-3-(TRIFLUOROMETHYL)BENZENEBORONIC ACID

There total 2 articles about 4-ETHOXY-3-(TRIFLUOROMETHYL)BENZENEBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H22BF3O3 → 4-ethoxy-3-(trifluoromethyl)phenylboronic acid (871329-83-8)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; hexanes; at 20 ℃;

Reference yield:

4-bromo-1-ethoxy-2-trifluoromethylbenzene (914635-58-8) → 4-ethoxy-3-(trifluoromethyl)phenylboronic acid (871329-83-8)

Guidance literature:

4-bromo-1-ethoxy-2-trifluoromethylbenzene; With n-butyllithium; In tetrahydrofuran; hexanes; water; at -78 - -70 ℃; for 0.0833333h;

With Triisopropyl borate; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h;

With acetic acid; In tetrahydrofuran; hexanes; water;

Reference yield: 72.0%

4-ethoxy-3-(trifluoromethyl)phenylboronic acid (871329-83-8) + C14H11BrN2O2S → C23H19F3N2O3S

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; at 150 ℃; for 1h; Microwave irradiation;

DOI:10.1080/14756366.2018.1501043

upstream raw materials:

4-bromo-1-ethoxy-2-trifluoromethylbenzene

Downstream raw materials:

4-amino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-3-nitro-pyridine-2-carbonitrile

C₂₆H₂₅F₃N₄O₂S

(1R)-2-({6-[4-(ethyloxy)-3-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethanol