4-broMo-2-(trifluoroMethyl)phenetole

Base Information

• Chemical Name: 4-broMo-2-(trifluoroMethyl)phenetole
• CAS No.: 914635-58-8
• Molecular Formula: C9H8BrF3O
• Molecular Weight: 269.061
• Hs Code.: 2909309090
• Mol file: 914635-58-8.mol

Synonyms:4-broMo-2-(trifluoroMethyl)phenetole

Chemical Property of 4-broMo-2-(trifluoroMethyl)phenetole

Chemical Property:

• PSA: 9.23000
• LogP: 3.86660
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-1-ethoxy-2-(trifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-broMo-2-(trifluoroMethyl)phenetole

There total 2 articles about 4-broMo-2-(trifluoroMethyl)phenetole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-(trifluoromethyl)phenol (50824-04-9) + ethyl iodide (75-03-6) → 4-bromo-1-ethoxy-2-trifluoromethylbenzene (914635-58-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 2.5h; Heating/reflux;

Reference yield:

ethanol (64-17-5) + 4-bromo-2-(trifluoromethyl)phenol (50824-04-9) → 4-bromo-1-ethoxy-2-trifluoromethylbenzene (914635-58-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; for 12h;

DOI:10.1016/j.bmcl.2010.06.043

Reference yield:

4-bromo-1-ethoxy-2-trifluoromethylbenzene (914635-58-8) → 4-ethoxy-3-(trifluoromethyl)phenylboronic acid (871329-83-8)

Guidance literature:

4-bromo-1-ethoxy-2-trifluoromethylbenzene; With n-butyllithium; In tetrahydrofuran; hexanes; water; at -78 - -70 ℃; for 0.0833333h;

With Triisopropyl borate; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h;

With acetic acid; In tetrahydrofuran; hexanes; water;

upstream raw materials:

4-bromo-2-(trifluoromethyl)phenol

ethyl iodide

ethanol

Downstream raw materials:

4-ethoxy-3-(trifluoromethyl)phenylboronic acid

C₁₇H₁₆F₃N₃O

2-[4-ethoxy-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 -. "6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS". Page/Page column 14-15. . Retrieved 2010/11/28.