cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

Base Information

Chemical Name:cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid
CAS No.:1153862-00-0
Molecular Formula:C₂₃H₂₅FN₂O₃
Molecular Weight:396.462
Hs Code.:

Synonyms:cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

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Chemical Property of cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

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Technology Process of cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

There total 1 articles about cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1153861-96-1
N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

: 1153862-00-0
cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

: (S)-cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

: (R)-cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

Guidance literature:: N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide; With acetic anhydride; acetic acid; sodium nitrite; at 0 - 20 ℃;

With water; sodium hydrogencarbonate; pH=9;

Reference yield: 40.0%

: trans-4-hydroxycyclohexylamine hydrochloride

: 1153862-00-0
cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

: 2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-N-(trans-4-hydroxy-cyclohexyl)-acetamide

Guidance literature:: cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 40 ℃; for 0.25h;

trans-4-hydroxycyclohexylamine hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 1153862-00-0
cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

: 76308-26-4
ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

: 1221227-58-2
(trans-4-{2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetylamino}-cyclohexyl)-acetic acid ethyl ester

Guidance literature:: cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 40 ℃; for 0.25h;

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

With sodium hydrogencarbonate; In water; pH=6;