N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

Base Information

Chemical Name:N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide
CAS No.:1153861-96-1
Molecular Formula:C₃₀H₃₂FN₃O₂
Molecular Weight:485.601
Hs Code.:

Synonyms:N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

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Chemical Property of N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

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Technology Process of N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

There total 2 articles about N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 362670-07-3
(2-amino-5-fluorophenyl)carbamic acid tert-butyl ester

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 3966-32-3
(R)-methoxyphenylacetic acid

: 2043-61-0
cyclohexanecarbaldehyde

: 1153861-96-1
N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

Guidance literature:: (2-amino-5-fluorophenyl)carbamic acid tert-butyl ester; cyclohexanecarbaldehyde; In methanol; at 20 ℃; for 0.5h;

Benzyl isocyanide; (R)-methoxyphenylacetic acid; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

Reference yield:

: 10340-91-7
isocyanomethyl-cyclohexane

: 1153861-96-1
N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

Guidance literature:: isocyanomethyl-cyclohexane; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

With water; sodium hydrogencarbonate; In 1,4-dioxane; pH=9;

Reference yield: 19.0%

: 1153861-96-1
N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide

: 1153862-00-0
cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

: (S)-cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

: (R)-cyclohexyl-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetic acid

Guidance literature:: N-benzyl-2-cyclohexyl-2-[5-fluoro-2-((R)-methoxy-phenyl-methyl)-benzoimidazol-1-yl]-acetamide; With acetic anhydride; acetic acid; sodium nitrite; at 0 - 20 ℃;

With water; sodium hydrogencarbonate; pH=9;