Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester
CAS No.:136061-43-3
Molecular Formula:C₁₅H₂₂O₄S
Molecular Weight:298.403
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

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Chemical Property of Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

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Technology Process of Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

There total 9 articles about Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 136061-42-2
2,4-Dimethylhex-4-en-1,3-diol

: 98-59-9
p-toluenesulfonyl chloride

: 136061-43-3
Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

Guidance literature:: With pyridine; at 22 ℃; for 20h;

Reference yield:

: 21665-16-7
O¹,O²;O⁵,O⁶-diisopropylidene-3-methylene-α-D-ribo-3-deoxy-hexofuranose

: 136061-43-3
Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / H₂, Et₃N / 10percent Pd/C / methanol / 5 h / 22 °C

2: 84 percent / 0.1 N H₂SO₄ / methanol / 5 h / 22 °C

3: 93 percent / pyridine / 20 h / 22 °C

4: 88 percent / LiAlH₄ / diethyl ether / 3 h / 35 °C

5: 93 percent / pyridiniumchloromate, Al₂O₃, NaOAc / CH₂Cl₂ / 24 h / 22 °C

6: nBuLi, (PhS)2 / tetrahydrofuran; benzene / 2.5 h / 22 °C / Irradiation

7: 76 percent / 1.4 N H₂SO₄ / dioxane / 48 h / 22 °C

9: 93 percent / pyridine / 20 h / 22 °C

With pyridine; aluminum oxide; lithium aluminium tetrahydride; n-butyllithium; pyridiniumchloromate; sulfuric acid; hydrogen; sodium acetate; triethylamine; diphenyldisulfane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; benzene;

Reference yield:

: 26293-58-3
(3aR,5S,6R,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,6-trimethyl-tetrahydrofuro[2,3-d][1,3]dioxole

: 136061-43-3
Toluene-4-sulfonic acid (E)-(2S,3S)-3-hydroxy-2,4-dimethyl-hex-4-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / 0.1 N H₂SO₄ / methanol / 5 h / 22 °C

2: 93 percent / pyridine / 20 h / 22 °C

3: 88 percent / LiAlH₄ / diethyl ether / 3 h / 35 °C

4: 93 percent / pyridiniumchloromate, Al₂O₃, NaOAc / CH₂Cl₂ / 24 h / 22 °C

5: nBuLi, (PhS)2 / tetrahydrofuran; benzene / 2.5 h / 22 °C / Irradiation

6: 76 percent / 1.4 N H₂SO₄ / dioxane / 48 h / 22 °C

8: 93 percent / pyridine / 20 h / 22 °C

With pyridine; aluminum oxide; lithium aluminium tetrahydride; n-butyllithium; pyridiniumchloromate; sulfuric acid; sodium acetate; diphenyldisulfane; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; benzene;