ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate

Base Information

• Chemical Name: ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate
• CAS No.: 225942-87-0
• Molecular Formula: C₄₂H₄₈N₂O₃
• Molecular Weight: 628.855

Synonyms:ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate

Chemical Property of ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate

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Technology Process of ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate

There total 6 articles about ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.2%

bis(4-isobutylphenyl)methyl chloride + ethyl 4-<3-(3-aminobenzoyl)-1H-indol-1-yl>butyrate (139156-03-9) → ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate (225942-87-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1248/cpb.47.481

Reference yield:

indole (120-72-9) → ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate (225942-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, 20 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 1 h

2: 90 percent / K₂CO₃ / dimethylformamide / 3 h / 40 °C

3: 86.3 percent / H₂ / 10 percent Pd/C / ethanol; dioxane / 0.75 h / 20 °C / 2280 Torr

4: 77.2 percent / iPr₂EtN / CH₂Cl₂ / Ambient temperature

With aluminium trichloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.481

Reference yield:

m-nitrobenzoic acid chloride (121-90-4) → ethyl 4-<3-<3-benzoyl>-1H-indol-1-yl>butyrate (225942-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, 20 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 1 h

2: 90 percent / K₂CO₃ / dimethylformamide / 3 h / 40 °C

3: 86.3 percent / H₂ / 10 percent Pd/C / ethanol; dioxane / 0.75 h / 20 °C / 2280 Torr

4: 77.2 percent / iPr₂EtN / CH₂Cl₂ / Ambient temperature

With aluminium trichloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.481

upstream raw materials:

ethyl 4-<3-(3-aminobenzoyl)-1H-indol-1-yl>butyrate

indole

m-nitrobenzoic acid chloride

3-(3-nitrobenzoyl)indole

Downstream raw materials:

[14C]-FK-143

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