(3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester

Base Information

• Chemical Name: (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester
• CAS No.: 1383381-38-1
• Molecular Formula: C₁₇H₂₀N₆O₄
• Molecular Weight: 372.384
• Mol file: 1383381-38-1.mol

Synonyms:(3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester

Chemical Property of (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester

There total 10 articles about (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-perillyl alcohol (536-59-4,18457-55-1) + temozolomide (85622-93-1) → (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester (1383381-38-1)

Guidance literature:

temozolomide; With oxalyl dichloride; In 1,2-dichloro-ethane; at 10 ℃; for 2.5h; Inert atmosphere; Reflux;

(-)-perillyl alcohol; In 1,2-dichloro-ethane; at 5 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

4-isopropylidene cyclohex-1-enyl methanol (110299-94-0) + C7H4N6O3 (1383381-37-0) → (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester (1383381-38-1)

Guidance literature:

In 1,2-dichloro-ethane; at 5 - 20 ℃; for 12.1667h; Inert atmosphere;

Reference yield:

4-(propan-2-ylidene)cyclohexan-1-one (19620-36-1) → (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester (1383381-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

2.1: aluminum isopropoxide / toluene / 7 h / Reflux

2.2: 20 °C

3.1: 1,2-dichloro-ethane / 12.17 h / 5 - 20 °C / Inert atmosphere

With potassium tert-butylate; aluminum isopropoxide; In dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;

upstream raw materials:

cyclohexanedione monoethylene ketal

temozolomide

4-(propan-2-ylidene)cyclohexan-1-one

8-(propan-2-ylidene)-1,4-dioxaspiro[4.5]decane

Refernces

• 1、 -. "METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL". . . Retrieved 2012/06/30.