19620-36-1

Upstream product

• 24903-95-5 nopinone 
• 113580-94-2 4-chloro-4-(1'-methylethyl)cyclohexan-1-one 
• 121-69-7 N,N-dimethyl-aniline 
• 19620-35-0 8-(propan-2-ylidene)-1,4-dioxaspiro[4.5]decane 
• 861575-49-7 8-bromo-6-oxo-m-menthan-7-oic acid ethyl ester 
• 861575-76-0 6-oxo-m-menth-3⁽⁸⁾-en-7-oic acid ethyl ester 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 7664-93-9 sulfuric acid 
• 4379-08-2 3-isopropenyl-pentane-1,3,5-tricarboxylic acid 

Downstream Products

• 586-81-2 γ-terpineol 
• 175020-74-3 4-isopropylidene-cyclohexanol 
• 6876-10-4 menthadiene-1⁽⁷⁾,4⁽⁸⁾ 
• 34126-59-5 4-(α-bromo-isopropyl)-cyclohexanone 
• 67-64-1 acetone 
• 637-88-7 1,4-Cyclohexanedione 
• 34131-94-7 4-isopropylidene-2-methylcyclohexanone 
• 1266339-07-4 (+)-2-fluoro-4-isopropylidenecyclohexanone 
• 1352653-81-6 (S)-2-benzoyloxy-4-isopropylidenecyclohexanone 
• 1383381-36-9 trifluoromethanesulfonic acid 4-isopropylidenecyclohex-1-enyl ester 
• 110299-94-0 4-isopropylidene cyclohex-1-enyl methanol 
• 1383381-38-1 (3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropylidene cyclohex-1-enylmethyl ester 
• 1383381-39-2 isoperillyl chloroformate 
• 1383381-40-5 4-(3-(cyclopentyloxy-4-methoxyphenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropylidenecyclohex-1-enylmethyl ester) 

Relevant academic research and scientific papers

Domino Aryne Annulation via a Nucleophilic-Ene Process

1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.

A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross-Coupling Reactions

Coupling of readily available boronic acids and diazo compounds has emerged recently as a powerful metal-free carbon–carbon bond forming method. However, the difficulty in forming the unstable diazo compound partner in a mild fashion has hitherto limited their general use and the scope of the transformation. Here, we report the application of oxadiazolines as precursors for the generation of an unstable family of diazo compounds using flow UV photolysis and their first use in divergent protodeboronative and oxidative C(sp2)?C(sp3) cross-coupling processes, with excellent functional-group tolerance.

METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an i

Spiro compounds or salts thereof and preventives/remedies for autoimmune diseases and AP-1 inhibitors containing the same

The spiro compounds of the present invention represented by the general formula: wherein A, R2, R3, R4, R5, R6and n are as defined in the specification, exhibit an AP-1 activity inhibitory action and, based on the AP-1 inhibitory action, suppresses the expression of a wide variety of genes and are useful as an agent for treating and preventing autoimmune diseases with lessoned side reactions.

Enantioselective synthesis of (+)-α-vetivone through the Michael reaction of chiral imines

(+)-α-Vetivone has been synthesised in nine steps. The absolute stereochemistry of the two stereogenic centres is controlled in the same key step involving the stereoselective Michael addition of a chiral imine of 4-isopropylidene-2-methylcyclohexanone to phenyl crotonate.

Halogenated Terpenoids. XXIX the 1-Bromo 1-Bromomethyl Cyclohexyl System

Bromination of methylene groups exocyclic to cyclohexyl systems normally affords two isomeric products; the axial 1-bromo equatorial 1-bromomethyl compound and the axial 1-bromomethyl equatorial 1-bromo derivative. Free energy differences between these two isomers, and the conformations adopted by the axial 1-bromomethyl group, have been explored by n.m.r. spectroscopy, by X-ray crystallography and by MM3 calculations. Evidence is presented to show that the ax-bromomethyl group exists primarily as those rotamers which site the bromine atom synclinal to the vicinal bromine. The A value for a bromomethyl group in this system is then similar to that of an unsubstituted methyl group.

The Interaction of π orbitals with a carbocation over three σ bonds

The semi-π analogue of double hyperconjugation ("hyperconjugation/conjugation") has been examined in 4-isopropylidenecyclohexyl mesylate (4-OMs) by comparison with the saturated analogue, trans-4-isopropylcyclohexyl mesylate (5-OMs). The unsaturated substrate reacts in 97% trifluoroethanol only four times faster than the saturated substrate. Raber-Harris plots indicate that both substrates react by ks mechanisms; i.e., solvolysis occurs with solvent assistance rather than carbocation formation. These results are consistent with the absence of a direct, through-bond interaction of the double bond with the reactive center. The absence is caused at least in part by less than ideal overlap of the γ,δ π orbitals with the α,β σ orbitals. In contrast, an electron-rich tin atom attached to the 4-position provides a large rate enhancement and changes the mechanism to carbocation formation through double hyperconjugation.