1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

Base Information

Chemical Name:1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one
CAS No.:908250-24-8
Molecular Formula:C₂₃H₂₃F₃N₂O₂
Molecular Weight:416.443
Hs Code.:

Synonyms:1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

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Chemical Property of 1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

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Technology Process of 1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

There total 3 articles about 1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 500581-73-7
3-(4-benzyloxy-3-methyl-phenyl)-3-oxo-propionic acid ethyl ester

: 908250-25-9
4-chloromethyl-3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazole

: 908250-24-8
1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran;

Reference yield: 65.0%

: 908250-25-9
4-chloromethyl-3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazole

: 908250-24-8
1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

Guidance literature:: 3-(4-benzyloxy-3-methyl-phenyl)-3-oxo-propionic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.666667h;

4-chloromethyl-3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazole; In tetrahydrofuran; for 23.3h; Heating / reflux;

With water; hydrogenchloride; In acetic acid; at 110 ℃; for 20h;

Reference yield:

: 628330-62-1
{3-isopropyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}methanol

: 908250-24-8
1-(4-hydroxy-3-methylphenyl)-3-[3-isopropyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / benzene

2: hydrogenchloride; sodium hydrogencarbonate; acetic acid / tetrahydrofuran

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; benzene;