1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine

Base Information

• Chemical Name: 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine
• CAS No.: 1012306-26-1
• Molecular Formula: C₃₄H₃₄N₂O₇
• Molecular Weight: 582.653
• Mol file: 1012306-26-1.mol

Synonyms:1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine

Chemical Property of 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine

There total 3 articles about 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + propargyl bromide (106-96-7) → 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine (1012306-26-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1021/jo702459b

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine (1012306-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 12 h / 20 °C

2: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube; Microwave irradiation

With pyridine; potassium carbonate; In methanol;

DOI:10.1016/j.tetlet.2018.12.018

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-propynyl)thymine (1012306-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 12 h / 20 °C

2: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube; Microwave irradiation

With pyridine; potassium carbonate; In methanol;

DOI:10.1016/j.tetlet.2018.12.018

upstream raw materials:

5'-O-(4-4'-dimethoxytrityl)thymidine

propargyl bromide

thymidine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

3-{1-[2-bis(2-azidoethyl)aminoethyl]-1,2,3-triazol-4-yl}methyl-1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-β-D-ibofuranosyl]thymine

N-(2-azidoethyl)-N,N-bis{4-[1-(2-deoxy-5-O-4′,4′′-dimethoxytrityl-β-dribofuranosyl)thymin-3-ylmethyl]-1,2,3-triazol-1-ylethyl}amine