N₂-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine
• CAS No.: 1440963-59-6
• Molecular Formula: C₁₅H₁₄F₃N₇O
• Molecular Weight: 365.318

Synonyms:N₂-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Chemical Property of N₂-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

There total 2 articles about N₂-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2-methoxy-4-(1H-1,2,4-triazol-1-yl)aniline (761440-72-6) + 2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine (515824-43-8) → N2-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1440963-59-6)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 1h;

Reference yield:

4-bromo-2-methoxyaniline (59557-91-4) → N2-(2-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (1440963-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 92 h / 110 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 1 h / 100 °C

With copper(l) iodide; caesium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

2-methoxy-4-(1H-1,2,4-triazol-1-yl)aniline

2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine

4-bromo-2-methoxyaniline

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