benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

Base Information

Chemical Name:benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine
CAS No.:608131-26-6
Molecular Formula:C₃₁H₂₈N₂O
Molecular Weight:444.576
Hs Code.:

benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1<i>H</i>-indol-6-yl]-amine

Synonyms:benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

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Technology Process of benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

There total 6 articles about benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 608131-24-4
Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

: 608131-26-6
benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

Guidance literature:: With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 16h;
DOI:10.1002/ejoc.200300123

Reference yield:

: 1013-88-3
Benzophenone imine

: 608131-26-6
benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 1,1'-bis(diphenylphosphanyl)ferrocene (DPPF); NaOtBu / Pd₂(dba)3 / toluene / 24 h / 100 °C

2: 92 percent / 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride; KOtBu / Pd₂(dba)3 / dioxane / 16 h / 100 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; toluene;
DOI:10.1002/ejoc.200300123

Reference yield:

: 31928-47-9
4-bromo-2-chloroiodobenzene

: 608131-26-6
benzhydrylidene-[2-cyclopropyl-1-(4-methoxy-phenyl)-2,3-dihydro-1H-indol-6-yl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / CuI; PPh₃; HN(iPr)2 / (PPh₃)2PdCl₂ / toluene / 6 h / 84 °C

2: Cp₂TiMe₂ / toluene / 24 h / 110 °C

3: 1.20 g / NaBH₃CN; ZnCl₂*Et₂O / diethyl ether; methanol; toluene / 12 h / 25 °C

4: 98 percent / 1,1'-bis(diphenylphosphanyl)ferrocene (DPPF); NaOtBu / Pd₂(dba)3 / toluene / 24 h / 100 °C

5: 92 percent / 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride; KOtBu / Pd₂(dba)3 / dioxane / 16 h / 100 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; zinc chloride diethyl ether; potassium tert-butylate; sodium cyanoborohydride; 1,3-bis(mesityl)imidazolium chloride; diisopropylamine; triphenylphosphine; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; dimethyltitanocene; In 1,4-dioxane; methanol; diethyl ether; toluene; 1: Sonogashira coupling;
DOI:10.1002/ejoc.200300123