(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid
CAS No.:1083091-83-1
Molecular Formula:C₃₄H₃₅ClFN₃O₅
Molecular Weight:620.12
Hs Code.:

(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

Synonyms:(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

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Chemical Property of (1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

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Technology Process of (1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

There total 7 articles about (1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083091-80-8
(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

: 1083091-83-1
(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

Guidance literature:: (1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; water;

Reference yield:

: C₂₄H₂₅ClN₂O₄*ClH

: 1083091-83-1
(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

2: methanol; lithium hydroxide; water / tetrahydrofuran / 20 °C

With methanol; lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 108-37-2
1-bromo-3-chlorobenzene

: 1083091-83-1
(1R,2S)-1-(6-(3-chiorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 6 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

6: methanol; lithium hydroxide; water / tetrahydrofuran / 20 °C

With hydrogenchloride; methanol; lithium hydroxide; 2,2,6,6-tetramethylheptane-3,5-dione; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;