(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

Base Information

Chemical Name:(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate
CAS No.:1083091-80-8
Molecular Formula:C₃₆H₃₉ClFN₃O₅
Molecular Weight:648.174
Hs Code.:

(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

Synonyms:(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

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Chemical Property of (1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

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Technology Process of (1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

There total 6 articles about (1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083091-82-0
(S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoic acid

: C₂₄H₂₅ClN₂O₄*ClH

: 1083091-80-8
(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

Reference yield:

: 6-hydroxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester

: 1083091-80-8
(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 6 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; 2,2,6,6-tetramethylheptane-3,5-dione; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 108-37-2
1-bromo-3-chlorobenzene

: 1083091-80-8
(1R,2S)-ethyl 1-(6-(3-chlorophenoxy)-2-((S)-2-(4-fluorophenylamino)-3,3-dimethylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-2-vinylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 6 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; 2,2,6,6-tetramethylheptane-3,5-dione; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;