4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide

Base Information

• Chemical Name: 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide
• CAS No.: 610270-90-1
• Molecular Formula: C₁₈H₁₂FN₃O
• Molecular Weight: 305.311
• Mol file: 610270-90-1.mol

Synonyms:4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide

Chemical Property of 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide

There total 11 articles about 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chloropyridin-3-yl)-[2-(4-fluorophenyl)-1-(1-oxy-pyridin-4-yl)ethylidene]amine (1075197-86-2) → 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide (610270-90-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

Reference yield:

4-[1-(2-chloropyridin-3-ylamino)-2-(4-fluorophenyl)vinyl]pyridin-1-ol → 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide (610270-90-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 98 - 100 ℃; for 5h;

DOI:10.1021/jm0301787

Reference yield:

3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine (223738-94-1) → 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-4-oxide + 4-(3-(4-fluorophenyl)-1H-pyrrolo-[3,2-b]pyridin-2-yl)pyridin-1-oxide (610270-90-1)

Guidance literature:

With meta-peroxy-benzoic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm0301787

upstream raw materials:

3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine

pyridine-4-carbaldehyde

4-pyridinecarboxylic acid, methyl ester

4-fluorophenylacetonitrile

Downstream raw materials:

2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

1-allyl-2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine