2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

Base Information

• Chemical Name: 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine
• CAS No.: 1075194-88-5
• Molecular Formula: C₂₀H₁₄ClF₂N₃
• Molecular Weight: 369.801
• Mol file: 1075194-88-5.mol

Synonyms:2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

Chemical Property of 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

There total 7 articles about 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoroethyl bromide (762-49-2) + 2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine (610270-92-3) → 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine (1075194-88-5)

Guidance literature:

2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine; With sodium hydride; In Pionier 2076; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-fluoroethyl bromide; In Pionier 2076; N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine (1075194-88-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid / methanol / 24 h / 20 °C / Reflux

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -70 °C

2.2: -70 - 20 °C

3.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane / 20 °C

4.1: 2 h / 130 °C / Inert atmosphere; Noeat (no solvent)

5.1: 1,4-diaza-bicyclo[2.2.2]octane / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 120 °C

6.1: trichlorophosphate / 1.5 h / 120 °C

7.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 0.5 h / 20 °C

7.2: 10 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium; sulfuric acid; dihydrogen peroxide; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; methyltrioxorhenium(VII); In tetrahydrofuran; methanol; hexane; dichloromethane; Pionier 2076; N,N-dimethyl-formamide;

Reference yield:

4-[2-(4-fluorophenyl)-1,1-dimethoxyethyl]pyridin-1-ol (610270-86-5) → 2-(2-chloropyridin-4-yl)-1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine (1075194-88-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2 h / 130 °C / Inert atmosphere; Noeat (no solvent)

2.1: 1,4-diaza-bicyclo[2.2.2]octane / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 120 °C

3.1: trichlorophosphate / 1.5 h / 120 °C

4.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 0.5 h / 20 °C

4.2: 10 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In Pionier 2076; N,N-dimethyl-formamide;

upstream raw materials:

pyridine-4-carbaldehyde

2-fluoroethyl bromide

2-(2-chloropyridin-4-yl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine

4-(dimethoxymethyl)pyridine

Downstream raw materials:

{4-[1-(2-fluoroethyl)-3-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}-(3-fluorophenyl)amine